Abstract:
Context: Cadmium has been considered as one of the most hazardous
toxic compounds with harmfully effect on the health of organisms.
Aims: To evaluate the effects of gallic acid (GA) on the cadmiuminduced liver and renal oxidative stress in Wistar rats.
Methods: Twenty Wistar rats were grouped into four (A–D) of five rats.
Rats in Group A, B, C and D were administered distilled water, 5
mg/kg bw cadmium chloride (CdCl2), CdCl2 + GA concurrently and GA
(20 mg/kg bw) respectively and administered for 14 days. Biochemical
parameters such as antioxidant enzyme activities, urea, creatinine and
myeloperoxidase activity were determined.
Results: In the urea, creatinine and MPO, there was a significant increase
in the CdCl2 treated group. In the liver, the CdCl2 treated group reduced
significantly the catalase activity and increased the reduced glutathione.
The gallic acid group increased in the GSH level, SOD, and CAT
activities and it also reduced significantly the MDA level. However, the
co-administration of CdCl2 + GA had a considerably increase in the
antioxidant enzymes. In the kidney, catalase activity and MDA level
significantly decrease and increase respectively. The gallic acid also
increases significantly the CAT and SOD activities while the MDA level
was reduced. Co-administration of GA + CdCl2 had a substantial
increase only in the SOD activity compared to the control.
Conclusions: This study indicates that gallic acid was able to protect the
alteration induced by cadmium chloride in the rat kidney and liver.
