dc.contributor.author |
Femi-Olabisi, Fehintoluwa Joy |
|
dc.contributor.author |
Faokunla, Opeyemi |
|
dc.contributor.author |
Olorunyolemi, Imoleayo Moses |
|
dc.date.accessioned |
2022-06-16T10:03:18Z |
|
dc.date.available |
2022-06-16T10:03:18Z |
|
dc.date.issued |
2019-10-28 |
|
dc.identifier.citation |
Femi-Olabisi F.J., Faokunla O., & Olorunyolemi I. M.(2019). Effects of Jatropha gossypifolia leaf Extract on the Reproductive Cycle of Cypermethrin-treated Female Rats. The Journal of Phytopharmacology; 8(5): 253-256 |
en_US |
dc.identifier.issn |
253-256 |
|
dc.identifier.uri |
http://localhost:8080/xmlui/handle/123456789/74 |
|
dc.description.abstract |
Cypermethrin (Cyp), a type II pyrethroid, is a broad-spectrum insecticide extensively used for pest
management and animal husbandry practices. They have been named among the endocrine disrupting
chemicals (EDCs). Previous studies have reported its adverse effect on reproduction with no detailed
information on the effect on female reproductive cycle. Methanolic extract of Jatropha gossypifolia leaves
was investigated for its attenuative effects on disrupted oestrous cycle and hormones of cypermethrintreated female wistar rats. Thirty-two female albino rats (180.23 ± 3.21 g) were completely randomized
into four groups (A- D) of eight animals each. Animals in group A served as the control and received 0.5
ml of corn oil. Animals in groups B, C and D received 20 mg/kg body weight (BW) of cypermethrin and
treated with 0.5 ml of corn oil, 50 and 100 mg/kg BW of Jatropha gossypifolia extract (JGE) respectively
on daily basis for 30 days and sacrificed 24 hours after the last administration. The oestrous cycle was
monitored by vaginal cytology between 09:00 and 10:00 hours throughout the exposure period. Four
reproductive hormones were assayed for in the serum of the animals: Progesterone (P), Testosterone (T),
Luteinizing hormone (LH) and Follicle stimulating hormone (FSH). The oestrous cycle was irregular in
female animals given cypermethrin and distilled water. The pattern of irregularity involves
persistent/extended estrus phase compared to the control group. The administration of 50 and 100 mg/kg
BW of JGE attenuated the effect of cypermethrin by reversing the irregularity in the oestrous cycle. The
administration of JGE attenuated the effect of cypermethrin on serum testosterone, progesterone, FSH and
LH concentrations. The phytoconstituents in the plant might be responsible for the attenuative benefits of
Jatropha gossypifolia leaves in the management of cypermethrin-induced alterations of the reproductive
cycle. |
en_US |
dc.description.sponsorship |
Femi-Olabisi Fehintoluwa Joy, Faokunla Opeyemi, Olorunyolemi Imoleayo Moses |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
The Journal of Phytopharmacology |
en_US |
dc.relation.ispartofseries |
8;5 |
|
dc.subject |
Cypermethrin, Jatropha gossypfolia, oestrus cycle, hormones, vaginal cytology. |
en_US |
dc.title |
Effects of Jatropha gossypifolia leaf Extract on the Reproductive Cycle of Cypermethrin-treated Female Rats |
en_US |
dc.type |
Article |
en_US |